Table 2 In vitro equilibrium dissociation constant (Kd) values (n = 3; mean ± SD) of [3H]PI-2620, [3H]florzolotau, [3H]OXD-2115, and [3H]OXD-2314 in AD, PSP, CBD, PiD, and PD frontal cortex tissues as well as P301L transgenic mouse tissue

From: Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

Radiotracer

AD

Kd (nM)

PSP

Kd (nM)

CBD

Kd (nM)

PiD

Kd (nM)

PD

Kd (nM)

P301L transgenic mice

Kd (nM)

Control

Kd (nM)

[3H]PI-2620

2.5 ± 1.8

5.3 ± 4.6

23 ± 4

n.d.

n.d.

n.d.

Undefined

[3H]Florzolotau

4.1 ± 0.5

4.6 ± 1.0

36 ± 7

20 ± 3

5.1 ± 1.1

n.d.

Undefined

[3H]OXD-2115

5.5 ± 1.9

4.9 ± 0.2

27 ± 1

34 ± 12

48 ± 11

n.d.

Undefined

[3H]OXD-2314

3.6 ± 0.7

2.4 ± 0.6

2.3 ± 0.3*

2.1 ± 0.3

2.2 ± 0.4*

1.1 ± 0.2

62 ± 8

5.1 ± 0.4

Undefined

  1. See Table S1 for demographics and neuropathology of subjects. n.d. not determined, undefined insufficient specific binding to fit the data. The AD, PSP, CBD, and PiD homogenates were pooled from three cases, the PD homogenates were pooled from 4 cases, and the Control was a representative single subject. *Subcortical tissue.
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