Fig. 7: Gradient-derived ROIs capture brain-behavior relationships.
From: Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease
a Cognitive correlates of tau SUVR within G1FC-derived (left), G1SC-derived (middle), or Braak meta-ROIs (right). Partial regression (absolute Pearson’s R) adjusted for age, sex, education, and APOE-ε4. Sample sizes of A+ participants varied across composite scores: word reading n = 87, delayed memory n = 76, immediate memory n = 82, executive function n = 86, object recognition n = 86, processing speed n = 84, and cognitive flexibility n = 81. b The resultant correlation coefficients changed in a topology-specific manner along the G1FC and G1SC but not the Braak axes (based on a linear regression between gradient bin ordering and the tau-cognition [z-scored] correlation coefficient within each bin, at two-sided PFDR < 0.05). c Z-statistic maps of the associations between meta-analytic cognitive terms and our primary functional (left), structural (middle), and tau-PET (right) CI template gradients. Terms are ordered by the weighted mean of their location along 5-percentile bins of the gradient. Source data are provided as a Source Data file. Abbreviations: CI cognitively impaired, FC functional connectivity, ROI region-of-interest, SC structural connectivity.
