Fig. 1: Strategies for catalytic asymmetric synthesis of chiral 1,2,3-triazoles. | Nature Communications

Fig. 1: Strategies for catalytic asymmetric synthesis of chiral 1,2,3-triazoles.

From: Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles

Fig. 1

a Synthesis of chiral 1,4-disubstituted triazoles by enantioselective Cu-catalyzed Click reaction. b Synthesis of chiral 1,4,5-trisubstituted triazoles by enantioselective Ni-catalyzed Click reaction. c Synthesis of chiral 1,4,5-trisubstituted triazoles by atroposelective Rh/Ir-catalyzed Click reaction. d This work: synthesis of chiral 1,5-disubstituted triazoles (unexplored) and 1,4,5-trisubstituted triazoles by enantioselective Cu-catalyzed azidation/Click cascade. Cat. catalyst, L ligand, Cu copper, Ni nickel, Rh rhodium, Ir iridium.

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