Fig. 3: Scope for the synthesis of chiral 1,4,5-trisubstituted triazoles. | Nature Communications

Fig. 3: Scope for the synthesis of chiral 1,4,5-trisubstituted triazoles.

From: Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles

Fig. 3

Reaction conditions: 4 (0.1 mmol), 1d (0.15 mmol), Cu(MeCN)4PF6 (5 mol %), L8 (6 mol %), CH2Cl2 (2 mL); the mixture was stirred at 25 °C for 48 h, then turned to 40 °C for more 48 h; isolated yields; ee values were determined by HPLC analysis. bThe absolute configuration was established to be R by the single-crystal X-ray structure analysis.

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