Fig. 1: General strategies for NCRs-directed remote C(sp3)−H functionalization.

a N-directed remote C(sp3)−H activation from N-heteroatom precursors. b Remote C(sp3)−H activation from free amines based on PCET. c Our hypothesis: remote C(sp3)−H activation from free amines based on ET/PT. d Reaction design. e This work: remote C(sp3)−H functionalization through ET/PT. PG protecting group, FG functional group, EWG electron-withdrawing group.