Fig. 2: Research on the scope of N-heteroarenes. | Nature Communications

Fig. 2: Research on the scope of N-heteroarenes.

From: Sulfonamide-directed site-selective functionalization of unactivated C(sp3)−H enabled by photocatalytic sequential electron/proton transfer

Fig. 2

Reaction conditions: heteroarenes 1 (0.2 mmol, 1.0 equiv), N-alkylsulfonamides 2a (0.4 mmol, 2.0 equiv), Mes-Acr+ClO4- (0.004 mmol, 2 mol%), [Co(dmgH)2Py]Cl (0.01 mmol, 5 mol%), TFA (0.4 mmol, 2.0 equiv), ACN/HFIP = 3:1 (2.0 mL, 0.1 M), 2 × 25 W blue LEDs (λ = 450−460 nm), room temperature, under a N2 atmosphere, 24 h. aK2S2O8 (0.4 mmol, 2.0 equiv), TFA (0.4 mmol, 2.0 equiv), ACN/H2O = 1:1 (2.0 mL, 0.1 M), 2 × 25 W purple LEDs (λ = 390−400 nm), room temperature, under a N2 atmosphere, 24 hours. PMP = 4-methoxybenzenesulfonyl.

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