Fig. 4: NCR-mediated intermolecular Minisci alkylation. | Nature Communications

Fig. 4: NCR-mediated intermolecular Minisci alkylation.

From: Sulfonamide-directed site-selective functionalization of unactivated C(sp3)−H enabled by photocatalytic sequential electron/proton transfer

Fig. 4

Reaction conditions: heteroarenes 1 (0.2 mmol, 1.0 equiv), alkanes (0.2 mL), HAT agent (0.04 mmol, 20 mol%), Mes-Acr+ClO4- (0.004 mmol, 2 mol%), [Co(dmgH)2Py]Cl (0.01 mmol, 5 mol%), TFA (0.4 mmol, 2.0 equiv), ACN/HFIP = 3:1 (2.0 mL), 2 × 25 W blue LEDs (λ = 450−460 nm), room temperature, under a N2 atmosphere, 24 hours. Ar1 6-chlorobenzo[d]thiazole, Ar2 2-phenylquinoline, Ar3 4-methylquinoline.

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