Fig. 5: Remote inert C(sp3)-H bonds functionalization. | Nature Communications

Fig. 5: Remote inert C(sp3)-H bonds functionalization.

From: Sulfonamide-directed site-selective functionalization of unactivated C(sp3)−H enabled by photocatalytic sequential electron/proton transfer

Fig. 5

Reaction conditions: 2a (0.2 mmol, 1.0 equiv), radical trapping reagents (0.6 mmol, 3.0 equiv), Mes-Acr+ClO4- (0.006 mmol, 3 mol%), ACN/HFIP = 9:1 (2.0 mL, 0.1 M), 2 × 25 W blue LEDs (λ = 450−460 nm), room temperature, under a N2 atmosphere, 24 h. aradical trapping reagents (0.4 mmol, 2.0 equiv), b1,2-diphenyldisulfane (0.04 mmol, 20 mol%), ACN/D2O = 9:1 (2.0 mL, 0.1 M).

Back to article page