Fig. 5: Expression pattern of APCDD1 in the human iris and embryonic mouse eyes. | Nature Communications

Fig. 5: Expression pattern of APCDD1 in the human iris and embryonic mouse eyes.

From: Altered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia

Fig. 5

a Immunofluorescence in the human iris with anti-APCDD1. APCDD1 protein is expressed in the anterior surface of the human iris, which overlaps with that of podoplanin (PDPN) but is separate from that of α-SMA. Scale bars, 100 μm (10× magnification), 50 μm (20× magnification), 10 μm (63× magnification). b Immunofluorescence of Apcdd1 in embryonic mouse eyes at E11.5, E13.5, E14.5, and E17.5, respectively. Apcdd1 is expressed in the peripheral inner layer of the neural retina from E11.5 to E14.5, and is confined to the boundary of the ciliary body and the retina at E17.5. Scale bars, 100 μm (whole eye) and 10 μm (63× magnification). These experiments were three times repeated indenpendently with similar results.

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