Fig. 2: rDNA copy number negatively correlates with BMI but the association is diminished by lifestyle interventions.
From: Ribosomal DNA copy number is associated with body mass in humans and other mammals
BMI clinical classifications are indicated (lean (BMI < 25 kg/m2) white background, overweight (25 kg/m2 < BMI < 30 kg/m2) blue background, obese (BMI > 30 kg/m2) red background). A Relative rDNA copy number is negatively correlated with BMI when the entire cohort is considered (Two-sided Spearman r = −0.1785, p = 0.0202, n = 169 individual males, non-medicated (open black squares), medicated (full grey squares)). B rDNA methylation is not correlated with BMI when the entire cohort is considered (Two-sided Spearman r = −0.1320, p = 0.0872, n = 169 individual males), non-medicated (open black squares), medicated (full grey squares)). C Relative rDNA copy number is negatively correlated with BMI when only non-medicated individuals are considered (Two-sided Spearman r = −0.2992, p = 0.0025, n = 100 individual males (open black squares)). D rDNA methylation is negatively correlated with BMI when only non-medicated individuals are considered (Two-sided Spearman r = −0.2518, p = 0.0115, n = 100 individual males (open black squares)). E Relative rDNA copy number is not correlated with BMI when only medicated individuals are considered (Two-sided Spearman r = 0.04607, p = 0.7070, n = 69 individual males, full grey squares). F rDNA methylation is not correlated with BMI when only medicated individuals are considered (Two-sided Spearman r = 0.06675, p = 0.5858, n = 69 individual males, full grey squares).
