Fig. 1: Schematic of the DGC probe identifying early AD by NIR-II imaging and multimodal analysis. | Nature Communications

Fig. 1: Schematic of the DGC probe identifying early AD by NIR-II imaging and multimodal analysis.

From: A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF

Fig. 1

The DGC probe can penetrate the blood–brain-barrier (BBB) of Alzheimer’s disease (AD) mice at early-stage (earlier than 3-month-old) in vivo, allowing noninvasive NIR-II imaging of elevated connective tissue growth factor (CTGF) in AD brain prior to the appearance of amyloid-beta (Aβ) plaque deposition.

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