Fig. 5: In vivo and ex vivo NIR-II images of DGC in AD mice brains.
From: A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
a The in vivo NIR-II images of APP/PS1 mice (right) and age-matched wild-type (WT) mice (left) from 1-month to 3-month-old after intravenous injection of DGC. b The ex vivo imaging of brains isolated from mice (cardiac perfusion with saline) after DGC injection for 4 h. c Ex vivo NIR-II imaging APP/PS1 mice brains aged from 1- to 9-month (n = 3). (λ ex = 808 nm). d Semi-quantitative analysis of the ex vivo NIR-II fluorescence (FL) intensity in APP/PS1 brains from 1-month to 9-month-old (n = 3). Data were presented as mean ± SD from three independent brains. ***P < 0.001 compared with the 1-month-old brain; Student’s t-test. Source data are provided as a Source Data file.
