Fig. 7: Specific DGC marking and imaging of CTGF in AD patient-derived brain sections and healthy control (HC) brain sections.
From: A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
a The fluorescence imaging of hippocampal and cortex regions in brain sections from AD patient and HC after staining with DGC (red fluorescence) and FITC-labeled-Aβ antibody (green fluorescence). The merge pictures show the partial colocalization of DGC and Aβ. Scale bar = 20 μm. b The fluorescence imaging of hippocampal and cortex regions in brain sections from AD patient and HC after staining with DGC (red fluorescence) and FITC-labeled CTGF antibody (green fluorescence). The merge pictures indicate the colocalization of DGC and CTGF. Scale bar = 20 μm. c Representative chromogenic imaging (brown) of hippocampal and cortex regions in brain sections from AD patient and HC after staining with DGC and DAB working solution. Scale bar = 20 μm. Each experiment was repeated independently in two AD patient-derived brain sections and two HC brain sections with similar results.
