Fig. 1: Locus discovery for global cortical thickness and white matter hyperintensities.
A, D Manhattan plots of loci associated with global cortical thickness (CT) and white matter hyperintensities (WMH) show the –log10(p-value) for each genomic location. A red line denotes the genome-wide significance threshold of two-sided P < 5 × 10−8. Results after correction for the 34 cortical thickness GWAS are shown in Supplementary Data 4. B Desikan–Killiany parcellation was used for regional thickness analyses (33 bilateral regions). E Ideogram of loci that influence global and regional cortical thickness and WMH. GWAS analyses were conducted in the UK Biobank (n = 35,846). T-statistics for genetic variants associated with memory and executive function in the Canadian Longitudinal Study of Ageing (C, CLSA) and in the UKB (F) after false discovery rate correction (q < 0.1). Congruent effects on cortical thickness and cognition are highlighted with a black square. G Polygenic scores for the thickness of prefrontal regions, such as the insula or superior frontal gyrus, were associated with executive function, while polygenic scores for the thickness of the anterior cingulate and entorhinal cortices were associated with memory in CLSA. Regions with a positive association at uncorrected p < 0.05 are highlighted in yellow; regions with a negative association at uncorrected p < 0.05 are highlighted in blue, while regions with a positive association at pFDR < 0.1 are highlighted in red. PAL paired associates learning, Gf fluid intelligence.
