Fig. 4: Gene-by-environment interactions on cortical thickness. | Nature Communications

Fig. 4: Gene-by-environment interactions on cortical thickness.

From: Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression

Fig. 4

A, B Cardiovascular conditions reduced cortical thickness (CT) in the insular regions and increased the total volume of white matter hyperintensities (WMH). Examples of interactions of rs9926320 (C, D, n = 34,204) and rs11126806 (F, G, n = 34,204) with cardiovascular conditions and an example of interaction between rs7575796 and depression (I, J, n = 34,204) on cortical thickness are shown. The effect magnitude of these clinical conditions was modified by genotype categories. A total of 49 significant interactions of genetic loci with cardiovascular conditions, 35 significant interactions with depression, and 11 significant interactions with both conditions (E, Supplementary Data 11–14, 21, 22) were found. Several polygenic risk scores (PRS) derived from the GWAS of regional thickness showed an interaction with cardiovascular health on executive function composite score in CLSA (H, Supplementary Data 15). In panels D, G, and J, means and 99.9% confidence intervals are plotted. All p-values are two-sided.

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