Fig. 4: Discrimination of resistant and susceptible isolates at 0xMIC-22h.

a Distance ratio (vertical axis), of data grouped by antimicrobial susceptibility, at different drug concentration against exposure time (horizontal axis). b PCoA plot for all datapoints at 0xMIC-22h. A subset from PCoA data (Fig. 2b) at 0xMIC-22h was reused for this plot. Yellow (susceptible) and dark purple (resistant) ellipses are 95%-confident ellipses. c The ten most important features derived from random forest, with 1,000 decision trees, identifying resistant isolate at 0xMIC-22h. Vertical axis is the important features against the importance on horizontal axis. d Heatmap of the ten most important features with hierarchical clustering on horizontal axis of datapoints and vertical axis of features. Each cell in the heatmap is the z-score value of a feature of a datapoint. A subset of z-score data from previous heatmap (Fig. 2a) was reused for the plot. e Representative images of D23580, SL1344, SL1344gyrA and VNS20081 at 0xMIC-2h (left column) and 0xMIC-22h (right column) taken from one well of one of two biological replicates. Source data are provided as a Source Data file.