Fig. 2: Proteome analysis of muscle from Icos-/- NOD mice developing myositis reveals the presence of mitochondrial anomalies.
From: IFNγ causes mitochondrial dysfunction and oxidative stress in myositis
a In-depth STRING proteome analysis of Icos-/- NOD vs. Icos+/+ NOD mice muscles showing identified dysregulated proteins classified by organelle. b IPA proteome analysis showing altered proteins belonging to the mitochondrial respiratory chain in the muscles of Icos-/- NOD vs. Icos+/+ NOD mice. Histograms represent normalized protein levels with respect to Icos+/+ NOD mice (100%) (n = 5 independent mice/group). Mean values ± s.e.m are shown. c IPA-generated schematic graphic representing dysregulated protein distribution in the mitochondrial respiratory chain (respiratory chain complexes I to V and O, for other). Statistical analysis was performed using the inbuilt Progenesis statistical box called ‘one-way ANOVA’. Numbers on graphs denote p values obtained by comparison of Icos-/- NOD vs. Icos+/+ NOD raw data. Source data are provided as a Source Data file.
