Fig. 1: TENT5 poly(A) polymerases are involved in both spermatogenesis and oogenesis. | Nature Communications

Fig. 1: TENT5 poly(A) polymerases are involved in both spermatogenesis and oogenesis.

From: TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice

Fig. 1

A Distribution of genotypes in pups of all Tent5 KO mouse lines from matings of heterozygous parents (only males were accounted for in the Tent5d KO line, in the Tent5b/c dKO mouse line, both parents had the Tent5b−/− Tent5c+/− genotype, and for this, only Tent5c genotype distribution is presented). P values reported for comparison with expected Mendelian ratios in Fisher’s exact test, two-tailed; n values represent the number of pups genotyped. B Fertility status of homozygous males and females of all Tent5 KO and Tent5b GFP-tagged mouse lines. C In-vitro maturation efficiency of Tent5a+/+ and Tent5a−/− GV oocytes. P value reported for comparing the ratio of metaphase II oocytes to other oocytes after 24 h of in-vitro culture in Fisher’s exact test, two-tailed; n values represent the number of oocytes analyzed; GV germinal vesicle, MI metaphase I, MII metaphase II. Source data are provided as a Source Data file.

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