Fig. 7: Proposed model for the activity of TENT5 proteins in gametogenesis.

Simplified diagrams of oogenesis (A) and spermatogenesis (B). Black t-lines with labels indicate stages disrupted by a particular mutation. Gradient boxes indicate approximate expression of Gld2 and Tent5b, c, and d genes at different stages of gametogenesis. C Proposed model for TENT5-mediated polyadenylation of transcripts encoding secreted proteins. After translation initiation, emerging signal peptide recruits the ribosome–mRNA complex to the ER, where further polyadenylation by TENT5 takes place.