Fig. 1: Histone H3 N-terminal arginine mutations are prevalent in cancer.

Using data from a published dataset of cancer-associated histone mutations¹⁸, A the frequency of mutations (y-axis) in histone H3 is plotted for each amino acid in the protein (x-axis) ranked by increasing frequency of mutations or B by sequence position with the single letter amino acid sequence of H3.1 noted (only positions 1–43 are shown). Blue indicates classical oncohistones. Red indicates H3 N-terminal arginine residues of interest. Selected sites of histone post-translational modifications⁶⁴ are denoted (Me methyl, Cit citrullination, Ac acetylation, Cr crotonylation, Bu butyrylation, Ub ubiquitination).