Fig. 3: Distribution of del(5q) cells within the CD34+ compartment of MDS patients. | Nature Communications

Fig. 3: Distribution of del(5q) cells within the CD34+ compartment of MDS patients.

From: Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide

Fig. 3

A UMAP representing all the MDS samples integrated and colored by cell type. The density map represents the distribution of the cells classified as del(5q) by the two algorithms. B UMAPs with density maps representing the distribution of del(5q) cells per individual patient. C Barplots showing the number of del(5q) and non-del(5q) cells composing each cell type for each MDS patient. D Heatmap representing the enrichment of del(5q) cells (-log10(p-value)) in each cell type. Any color different from white represents a statistically significant enrichment of del(5q) cells (p-value < 0.05). p-values were calculated using the one-sided hypergeometric test. The number of biologically independent replicates (cells) used for the hypergeometric test and the exact enrichment p-values can be found in the Source Data.

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