Fig. 5: Cell-to-cell communication analysis reveals shared and unique interactions in del(5q), non-del(5q) and healthy cells. | Nature Communications

Fig. 5: Cell-to-cell communication analysis reveals shared and unique interactions in del(5q), non-del(5q) and healthy cells.

From: Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide

Fig. 5

A Venn diagram showing the number of unique interactions in del(5q) MDS and healthy samples. Healthy unique interactions were considered as those present in at least one of the healthy individuals, while MDS unique interactions were those that were present in all the patients. Interactions were inferred from n = 4 del(5q) MDS patients and n = 3 healthy donors. B Heatmap depicting the number of interactions triggered by del(5q) and non-del(5q) MDS cells, C as well as those established among healthy hematopoietic progenitors. The Source represents the cell types that express the ligand, whereas the Target represents the cells that express the receptor. D Dotplot representing statistically significant biological processes and pathways (Benjamini–Hochberg-adjusted p-value < 0.05) in which are enriched the encoding genes taking part in the healthy and MDS interactions. The one-sided hypergeometric test was used to calculate p-values, whose exact values can be found in the Source Data. E Chord diagram representing the unique MDS interaction AGTRAP-RACK1 among different del(5q) and non-del(5q) progenitors. F Chord diagram depicting the unique healthy interaction HMGB1-CXCR4 established by healthy hematopoietic progenitors.

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