Fig. 9: Model depicting effects of reduced extracellular K+ on PT cell physiology. | Nature Communications

Fig. 9: Model depicting effects of reduced extracellular K+ on PT cell physiology.

From: Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2

Fig. 9

Reduced blood K+ along the basolateral membrane leads to K+ efflux via Kir4.2, which reduces membrane voltage (Vm). This promotes Cl- efflux through VRAC, decreased intracellular Cl- concentration [Cl-], and activates mTORC2 to phosphorylate AKT. This has broad effects on cell physiology including increasing transcription/translation, Na+ reabsorption, and PT expansion. Figure 9 created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en.

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