Fig. 3: Overview and prognostic impact of TIME profiling in pediatric LGG. | Nature Communications

Fig. 3: Overview and prognostic impact of TIME profiling in pediatric LGG.

From: Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment

Fig. 3

a Boxplot of TIS across genomic subtypes of LGGs. Boxes show the median and interquartile range (IQR) of the data with whiskers extending to ±1.5 IQR. P-values by two-tailed T test with Holm adjustment. b Boxplots of TIS scores for PLGG split by location and by histologic type. Boxes show the median and IQR with whiskers extending to ±1.5 IQR. P-values by two-tailed T test with Holm adjustment. (Diffuse glioma category includes diffuse astrocytomas and oligodendrogliomas; PXA: pleomorphic xantho-astrocytoma; DNT: dysembryoplastic neuroepithelial tumor). c Volcano plot of differentially expressed genes between PLGG with BRAF SNV (single nucleotide variant) and BRAF fusion. P-values by two-tailed T test with BH adjustment. d Kaplan–Meier curves of high vs low TIS scores in BRAF-mutant and BRAF-fused PLGG. P-values by log-rank test.

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