Fig. 7: TIME alterations with immune checkpoint inhibition (ICI). | Nature Communications

Fig. 7: TIME alterations with immune checkpoint inhibition (ICI).

From: Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment

Fig. 7

a Scatter plot comparing longitudinal TIS scores pre- and post-ICI treatment in four MMRD HGGs with matched tissue samples. b Heatmap of NanoString counts for selected genes pre- and post-ICI treatment for four patients with longitudinal sampling. c Representative MRI and histology (CD8 and PD-L1 IHC) images of pre-ICI treatment and post-treatment samples from a patient with MMRD HGG. Scale bars (bottom left) are 100 μm for CD8 (images taken at ×100 magnification) and 50 μm for PD-L1 (images taken at ×200 magnification).

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