Fig. 6: Phenotype-based drug repurposing for the treatment of pancreatic cancer. | Nature Communications

Fig. 6: Phenotype-based drug repurposing for the treatment of pancreatic cancer.

From: Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery

Fig. 6

a The flow chart of drug repurposing strategy. b The screening performance of phenotype-based strategy and structural similarity-based strategy. c TranSiGen_DISEASE screened compounds that are capable of inhibiting pancreatic cancer cells, and their max structural similarities to approved drugs. d The rankings of thiostrepton and resibufogenin from different screening strategies. e Top 50 compounds screened by TranSiGen_DISEASE and their respective cell proliferation inhibition activities. f Top 50 compounds screened by TranSiGen_DRUG and their corresponding cell proliferation inhibition activities. Source data are provided as a Source Data file.

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