Fig. 10: IFNγ-IL12 axis is upregulated in human subjects with MASH. | Nature Communications

Fig. 10: IFNγ-IL12 axis is upregulated in human subjects with MASH.

From: IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease

Fig. 10

PolyA-selected RNA-seq data from 206 patients diagnosed with MASLD/MASH from the NICBI GEO database (accession number: GSE135251) were analyzed to evaluate differential gene expression in human subjects with MASLD/MASH. The data were stratified into 5 groups: 51 patients with MASLD, 34 patients with MASH fibrosis stage F0-F1, 53 patients with F2-MASH, 54 patients with F3-MASH, and 14 patients with F4-MASH. A IFNγR1, B IFNγR2, C IL-12A, D IL-12B, and E FGF21. The counts were normalized to Fragments Per Kilobase of transcript per Million (FPKM). The statistical significance of the difference in mean values was determined using a two-sided Wilcoxon-Mann-Whitney test. Lower bound (Q1): 25%, upper bound (Q3): 75%, and centre (median): 50%. Interquartile Range (IQR): Q3-Q1. Minima (lower whisker end): Q1-1.5xIQR. Maxima (upper whisker end): Q3 + 1.5xIQR.

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