Fig. 6: Reduced biomarkers for liver fibrosis and HSC activation in Lyz-IFNγR2−/− mice following the GAN diet. | Nature Communications

Fig. 6: Reduced biomarkers for liver fibrosis and HSC activation in Lyz-IFNγR2−/− mice following the GAN diet.

From: IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease

Fig. 6

Liver hydroxyproline and α-smooth muscle actin (α-SMA) contents were measured as reliable markers of fibrosis and activation of hepatic stellate cells (HSC), respectively. A Hydroxyproline content in liver samples collected from WT mice (n = 10) and Lyz-IFNγR2−/− mice (KO; n = 11) after 20 weeks of the GAN diet. B Percent coverage of α-SMA stain in liver sections from WT and KO mice after the GAN diet (n = 3 per genotype). C Histology images showing α-SMA stain for WT1, WT2, KO1, and KO2 mice with stain areas highlighted in red. Data are presented as mean ± SEM values. The statistical significance of the difference in mean values was determined using a two-tailed Student’s t-test.

Back to article page