Table 1 Characteristics (number [%]) of the population under study – dose 1 cohort

Total

All

45,673,965

8,424,120 (18.44%)

19,317,985 (42.30%)

16,846,995 (36.89%)

1,084,865 (2.38%)

Sex

Male

22,607,555 (49.5%)

4,718,635 (56.01%)

9,421,000 (48.77%)

7,875,835 (46.75%)

592,085 (54.58%)

Female

23,066,410 (50.5%)

3,705,480 (43.99%)

9,896,985 (51.23%)

8,971,165 (53.25%)

492,780 (45.42%)

Age (years)

18–29

8,847,920 (19.4%)

2,776,200 (32.96%)

1,021,805 (5.29%)

4,572,045 (27.14%)

477,870 (44.05%)

30–39

8,484,105 (18.6%)

2,450,210 (29.09%)

1,630,695 (8.44%)

4,020,215 (23.86%)

382,985 (35.30%)

40–49

7,540,600 (16.5%)

1,430,495 (16.98%)

4,322,935 (22.38%)

1,585,815 (9.41%)

201,355 (18.56%)

50–59

7,700,005 (16.9%)

865,605 (10.28%)

5,284,090 (27.35%)

1,534,230 (9.11%)

16,080 (1.48%)

60–69

5,871,400 (12.9%)

474,340 (5.63%)

3,762,510 (19.48%)

1,629,755 (9.67%)

4795 (0.44%)

70–79

4,594,010 (10.1%)

248,830 (2.95%)

2,529,425 (13.09%)

1,814,400 (10.77%)

1355 (0.12%)

80–89

2,157,220 (4.72%)

130,310 (1.55%)

575,940 (2.98%)

1,450,595 (8.61%)

375 (0.03%)

90+

478,710 (1.05%)

48,130 (0.57%)

190,590 (0.99%)

239,940 (1.42%)

50 (0.00%)

Ethnic group

Asian

3,740,455 (8.19%)

855,560 (10.16%)

1,316,815 (6.82%)

1,488,545 (8.84%)

79,535 (7.33%)

Black

1,675,070 (3.67%)

651,935 (7.74%)

489,720 (2.54%)

497,755 (2.95%)

35,660 (3.29%)

Mixed

717,695 (1.57%)

249,425 (2.96%)

196,505 (1.02%)

248,795 (1.48%)

22,970 (2.12%)

Other

1,448,035 (3.17%)

626,600 (7.44%)

361,545 (1.87%)

422,270 (2.51%)

37,620 (3.47%)

White

36479155 (79.9%)

5285020 (62.74%)

16,524,935 (85.54%)

13,798,605 (81.91%)

870,595 (80.25%)

Unknown/Missing

1,613,555 (3.53%)

755,580 (8.97%)

428,465 (2.22%)

391,025 (2.32%)

38,485 (3.55%)

Index of multiple deprivation (1 most, 10 leas deprived)

1–2

8,651,540 (18.9%)

2,294,285 (27.23%)

3,253,630 (16.84%)

2,926,715 (17.37%)

176,910 (16.31%)

3–4

9,015,905 (19.7%)

2,090,015 (24.81%)

3,535,865 (18.30%)

3,184,335 (18.90%)

205,690 (18.96%)

5–6

8,815,855 (19.3%)

1,554,155 (18.45%)

3,803,565 (19.69%)

3,258,740 (19.34%)

199,395 (18.38%)

7–8

8,580,765 (18.8%)

1,198,325 (14.22%)

3,948,195 (20.44%)

3,240,875 (19.24%)

193,370 (17.82%)

9–10

8,300,280 (18.2%)

922,005 (10.94%)

4,037,545 (20.90%)

3,143,075 (18.66%)

197,655 (18.22%)

Missing

2,309,620 (5.06%)

365,330 (4.34%)

739,185 (3.83%)

1,093,260 (6.49%)

111,845 (10.31%)

Smoking status

Current

7,788,670 (17.1%)

2,216,230 (26.31%)

3,000,925 (15.53%)

2,385,020 (14.16%)

186,495 (17.19%)

Former

10,414,755 (22.8%)

1,267,720 (15.05%)

5,255,825 (27.21%)

3,728,875 (22.13%)

162,335 (14.96%)

Never

25,332,265 (55.5%)

4,158,860 (49.37%)

10,754,915 (55.67%)

9,790,240 (58.11%)

628,250 (57.91%)

Missing

2,138,275 (4.68%)

781,300 (9.27%)

306,325 (1.59%)

942,865 (5.60%)

107,785 (9.94%)

Medical history

AMI

1,161,760 (2.54%)

85,295 (1.01%)

567,515 (2.94%)

507,980 (3.02%)

970 (0.09%)

Diabetes

3,907,740 (8.56%)

301,965 (3.58%)

1,999,260 (10.35%)

1,598,265 (9.49%)

8250 (0.76%)

Depression

9,426,550 (20.6%)

1,325,580 (15.74%)

4,602,700 (23.83%)

3,328,455 (19.76%)

169,815 (15.65%)

Obesity

4,384,350 (9.60%)

402,695 (4.78%)

2,298,955 (11.90%)

1,639,185 (9.73%)

43,515 (4.01%)

Cancer

6,465,720 (14.2%)

576,160 (6.84%)

3,122,945 (16.17%)

2,664,130 (15.81%)

102,485 (9.45%)

COPD

1,549,765 (3.39%)

116,345 (1.38%)

798,160 (4.13%)

633,205 (3.76%)

2055 (0.19%)

Liver disease

225,630 (0.49%)

32,055 (0.38%)

117,550 (0.61%)

75,170 (0.45%)

855 (0.08%)

CKD

2,867,785 (6.28%)

214,160 (2.54%)

1,346,545 (6.97%)

1301,275 (7.72%)

5805 (0.54%)

Dementia

510,600 (1.12%)

49,230 (0.58%)

268,085 (1.39%)

193,075 (1.15%)

210 (0.02%)

All stroke

835,305 (1.83%)

67,115 (0.80%)

423,070 (2.19%)

344,140 (2.04%)

980 (0.09%)

All VTE

642,035 (1.41%)

66,330 (0.79%)

329,515 (1.71%)

244,180 (1.45%)

2010 (0.19%)

Thrombophilia

43,440 (0.10%)

5130 (0.06%)

20,795 (0.11%)

17,020 (0.10%)

495 (0.05%)

Major surgery in the last year

3,438,335 (9.23%)

423,490 (5.03%)

732,470 (5.17%)

1,602,550 (9.51%)

 53,680 (4.95%)

No. of unique diseases in the last year

0

36,130,080 (79.1%)

7,478,345 (88.77%)

14,694,520 (76.07%)

13,005,675 (77.20%)

951,540 (87.71%)

1–5

9,412,710 (20.6%)

933,460 (11.08%)

4,554,595 (23.58%)

3,791,520 (22.51%)

133,135 (12.27%)

6+

131,170 (0.29%)

12,300 (0.15%)

68,875 (0.36%)

49,805 (0.30%)

190 (0.02%)

Region

Northwest

5,658,370 (12.4%)

1,006,965 (11.95%)

2,423,155 (12.54%)

2,106,490 (12.50%)

121,760 (11.22%)

Southeast

6,574,915 (14.4%)

1,007,385 (11.96%)

3,002,770 (15.54%)

2,378,170 (14.12%)

186,590 (17.20%)

London

7,210,945 (15.8%)

2,248,485 (26.69%)

2,356,510 (12.20%)

2,429,115 (14.42%)

176,835 (16.30%)

East of England

4,040,560 (8.85%)

663,225 (7.87%)

1,830,055 (9.47%)

1,455,715 (8.64%)

91,565 (8.44%)

Southwest

3,574,255 (7.83%)

463,450 (5.50%)

1,616,385 (8.37%)

1,397,850 (8.30%)

96,570 (8.90%)

Yorkshire/Humber

5,096,465 (11.2%)

714,715 (8.48%)

1,900,555 (9.84%)

1,517,425 (9.01%)

113,245 (10.44%)

East Midlands

4,245,940 (9.30%)

484,935 (5.76%)

1,434,740 (7.43%)

1,192,780 (7.08%)

13,055 (1.20%)

West Midlands

3,125,510 (6.84%)

821,550 (9.75%)

1,942,855 (10.06%)

1,627,415 (9.66%)

70,815 (6.53%)

Northeast

4,462,635 (9.77%)

254,925 (3.03%)

761,420 (3.94%)

628,785 (3.73%)

39,240 (3.62%)

Missing

1,684,370 (3.69%)

758,495 (9.00%)

2,049,535 (10.61%)

2,113,255 (12.54%)

175,180 (16.15%)

Prior COVID-19 at index date

2,496,910 (5.5%)

119,535 (1.42%)

464,180 (2.40%))

488,985 (2.90%))

 29,215 (2.69%)

Medications taken in the last 3 months

Antiplatelet

119,325 (1.42%)

142,340 (1.00%)

1,215,145 (6.29%)

1,108,890 (6.58%)

2445 (0.23%)

Blood pressure lowering

8,390,090 (18.4%)

367,775 (4.37%)

4,520,250 (23.40%)

3,486,990 (20.70%)

15,075 (1.39%)

Lipid lowering

6,651,900 (14.6%)

241,945 (2.87%)

3,552,420 (18.39%)

2,851,365 (16.93%)

6170 (0.57%)

Anticoagulant

1,300,380 (2.85%)

64,025 (0.76%)

613,405 (3.18%)

622,200 (3.69%)

750 (0.07%)

COCP

612,760 (1.34%)

67,420 (0.80%)

143,415 (0.74%)

368,470 (2.19%)

33,455 (3.08%)

HRT

530,515 (1.16%)

20,320 (0.24%)

350,180 (1.81%)

156,765 (0.93%)

3250 (0.30%)

Clinically vulnerable

Neither

35,461,085 (77.6%)

7,547,780 (89.60%)

14,122,735 (73.11%)

12,731,880 (75.57%))

1,058,690 (97.59%)

Vulnerable

8,084,085 (17.7%)

711,505 (8.45%)

4,094,310 (21.19%)

3,255,215 (19.32%)

23,055 (2.13%)

Extremely vulnerable

2,128,795 (4.66%)

164,830 (1.96%)

1,100,945 (5.70%)

859,900 (5.10%)

3120 (0.29%)