Fig. 2: Vpr downmodulates PU.1-dependent transcription.
From: HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages

A PU.1 motifs identified by HOMER as present in the promoters of Vpr-downmodulated genes (Fig. 1I, Blue). B Violin plots displaying RNA abundance of the indicated transcription factor genes in MDMs infected with the indicated virus. C Volcano plot as in Fig. 1I except that genes containing a PU.1 or PU.1-IRF binding motif in their promoter region are highlighted in green (see also Supplementary Fig. 2). D Biological processes associated with the PU.1 targeted genes from C. Size of circles indicates the relative number of GO terms associated with the process. FDR adjusted q-values associated with GO terms are indicated by the color. Bolded rings are associated with biological processes listed. E Violin plots displaying RNA abundance of the indicated genes in MDMs infected with the indicated virus. HIV-1 89.6wt (WT); HIV-1 89.6∆vpr (∆Vpr). False-discovery rate corrected two-sided Wilcoxon rank-sum p-values are shown above the conditions being compared.