Fig. 6: LW6 protects mice from pulmonary mucormycosis.
From: Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis
(A Survival of neutropenic mice (40 per group from three experiments) infected intratracheally with R. delemar (average inoculum of 1.1×10^4 spores per mouse) and treated with vehicle control (placebo) or 15 mg/kg LW6 24 h post infection for 4 consecutive days. (B) Inhibition of the HIF1α by LW6 did not affect the fungal burden in the lungs of mice harvested on Day +4 post infection. Data from one experiment (10 mice per group) and presented as median + interquartile range. Statistical analysis was performed by using Mann-Whitney non-parametric (two-tailed) test comparing treated groups vs. placebo group.
