Fig. 6: The corneal structure variation after A-CXL treatment. | Nature Communications

Fig. 6: The corneal structure variation after A-CXL treatment.

From: Development of graphitic carbon nitride quantum dots-based oxygen self-sufficient platforms for enhanced corneal crosslinking

Fig. 6

a Schematic of a simple operation flow chart of A-CXL evaluation using Corvis® ST and Optovue RTVue OCT. b Comparison of A1L (mean ± SD, n = 5, (for RF 9 mW cm−2 group, n = 4, one rabbit died on Day 10), two-way ANOVA multiple comparison test, P1 = 0.0003, P2 = 0.0018, P3 = 0.0196 P4 = 0.0061, P5 = 0.0257, P6 = 0.0014, P7 = 0.0210, P8 < 0.0001, P9 = 0.0406, P10 < 0.0001, P11 = 0.0048, P12 < 0.0001, P13 = 0.0033, P14 = 0.0381, P15 = 0.0335, P16 < 0.0001, P17 < 0.0001, P18 < 0.0001, P19 = 0.0057, P20 = 0.0153, the absence of a P-value indicates no statistical difference between the groups (p > 0.05)). c Comparison of A2V (mean ± SD, n = 5, (for RF 9 mW cm−2 group, n = 4, one rabbit died on Day 10), two-way ANOVA multiple comparison test, P1 < 0.0001, P2 = 0.0001, P3 = 0.0024, P4 = 0.0052. P5 = 0.0089, P6 = 0.0007, P7 = 0.0009, P8 = 0.0355, P9 = 0.0229, P10 = 0.0144, P11 = 0.0089, P12 = 0.0001, P13 = 0.0113, P14 = 0.0121, P15 = 0.0024, P16 = 0.0054, the absence of a P-value indicates no statistical difference between the groups (p > 0.05)). d Comparison of HC-R (mean ± SD, n = 5, (for RF 9 mW cm−2 group, n = 4, one rabbit died on Day 10), two-way ANOVA multiple comparison test, P1 = 0.0368, P2 < 0.0001, P3 = 0.0002, P4 = 0.0386. P5 < 0.0001, P6 = 0.0002, P7 = 0.0016, P8 = 0.0014, P9 = 0.0048, P10 = 0.0076, P11 = 0.0131, P12 = 0.0199, P13 = 0.0026, P14 = 0.0012, P15 = 0.0377, P16 = 0.0455, the absence of a P-value indicates no statistical difference between the groups (p > 0.05)). e Comparison of HC-DA (mean ± SD, n = 5, (for RF 9 mW cm−2 group, n = 4, one rabbit died on Day 10), two-way ANOVA multiple comparison test, P1 = 0.0003, P2 < 0.0190, P3 = 0.0310, P4 = 0.0087, P5 = 0.0493, P6 = 0.0135, P7 = 0.000, P8 = 0.0019, P9 = 0.0066, P10 = 0.0493, P11 = 0.0021, P12 = 0.0079, P13 = 0.0190, the absence of a P-value indicates no statistical difference between the groups (p > 0.05)). f Photos of OCT images. g Comparison of the CCT (mean ± SD, n = 4, two-way ANOVA multiple comparison test, the absence of a P-value indicates no statistical difference between the groups (p > 0.05)).

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