Fig. 4: Structures of neutralizing antibodies bound to S1B reveal cryptic epitopes in PDCoV S trimer. | Nature Communications

Fig. 4: Structures of neutralizing antibodies bound to S1B reveal cryptic epitopes in PDCoV S trimer.

From: Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Fig. 4

A Atomic model representation of the PDCoV S1B (blue) bound to 67B12 antibody ab fragment (medium purple and yellow) and the 42H3/46E6 antibody Fab fragments (purple and pink). B The interaction of hAPN (surface representation-orange) with the S1B of PDCoV (PDB:7VPQ) overlayed onto the atomic structure of the S1B-Fab complexes. C, D S1B-Fab complexes overlayed onto the surface representative of the PDCoV S trimer displayed from two perpendicular viewpoints showing that the 67B12 and 42H3/46E6 epitopes are inaccessible in the closed trimer.

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