Fig. 1: A summary of the analysis pipeline of the current study. | Nature Communications

Fig. 1: A summary of the analysis pipeline of the current study.

From: Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals

Fig. 1

a The UK Biobank data used in the current study, including quantitative susceptibility mapping (QSM) features derived from susceptibility-weighted MRI, whole-exome sequencing data and phenotypic data. b Exome-wide association study (EWAS) of brain iron with rare and common variants. c Validation study and replication analysis of EWAS. d Post EWAS analysis, including gene set enrichment analysis, protein–protein interaction, tissue and single-cell expression, and e phenotype-wide association study and Mendelian randomization analysis. swMRI susceptibility-weighted MRI, QSM quantitative susceptibility mapping, MR Mendelian randomization, IVW inverse variance weighted. This figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 4.0 unported license.

Back to article page