Fig. 5: Phenome-wide association analysis of brain iron-associated genes. | Nature Communications

Fig. 5: Phenome-wide association analysis of brain iron-associated genes.

From: Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals

Fig. 5

a Phenome-wide associations of genes mapped from rare variants. b Phenome-wide associations of genes mapped from common variants. Scatterplot showing associations between brain iron-related genes and a wide range of phenotypes, including 12 categories, listed at the bottom left of each figure. The y-axis indicates the \({-\log }_{10}\) of the p-value for each association, and the x-axis represents different phenotype categories. The p-values shown are two-sided and unadjusted for multiple testing. Linear regression models and SKAT-O tests were used for gene-based analysis, and the model adjusted for age, gender, and top 10 ancestral principal components. Red line in each figure is the FDR 0.05 correction threshold. CVD cardiovascular disease, FEV1 forced expiratory volume in 1 s, FEV1_Best best measure of FEV1, FEV1_predperc predicted percentage of FEV1TP, total protein, HDLC high-density lipoprotein cholesterol, LDLC low-density lipoprotein cholesterol, WBC white blood cell count, Neu_c neutrophil count, PLT platelet count, HBA1C glycated hemoglobin, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammation index.

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