Fig. 5: The induction of IFN, ISG and SASP genes in BJ-RASV12 cells depends on MRE11.
From: MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
a BJ-RASV12 fibroblasts were induced for 8 days with 10 μg/ml Dox in the presence or the absence of 10 μM Mirin. Volcano plots of differentially expressed IFN, ISG and SASP genes between control and RAS-induced BJ cells treated or not with Mirin are shown. Data are from biological triplicates. b Levels of IL6 and CXCL1 expression were quantified by RT-qPCR. Mean ± SD of one representative experiment of two independent experiments is shown (n = 2). Source data are provided as a Source Data file.
