Fig. 4: Burden heritability and genetic correlations of IMDs.

A The burden heritability of IMDs calculated by burden heritability regression (“Methods” section). The x-axis indicates the specific IMDs and the y-axis indicates the heritability based on rare variants. The graph showcases the aggregate heritability for each disease and highlights the most impactful category of heritability for each phenotype. B Significant genetic correlations between the 30 IMDs with identified rare variants. Only substantial pairwise correlations (with a correlation coefficient, rg > 0.3) are emphasized, with weaker correlations appearing nearly transparent. The size of each node (represented by circles) indicates the number of significant correlations associated with a particular phenotype. The intensity of the line color between nodes conveys the strength and direction of the correlation coefficient. IMD immune-mediated disease, BHR burden heritability regression, pLOF predicted loss-of-function, MAF minor allele frequency, pmis predicted deleterious missense, RF rheumatic fever, MS multiple sclerosis, MG myasthenia gravis, Sicca Sicca syndrome (Sjogren’s syndrome), NV necrotizing vasculopathies, Behcet Behcet’s disease, AS ankylosing spondylitis, SD sarcoidosis, PA pernicious anemia, ITP idiopathic thrombocytopenic purpura, AP allergic purpura, HPT autoimmune hypothyroidism, Graves Graves’ disease, T1D diabetes mellitus (Type I), PBC primary biliary cirrhosis, Hepatitis autoimmune hepatitis, Crohn Crohn’s disease, Celiac Celiac disease, ADGC allergic and dietetic gastro-enteritis and colitis, SLE systemic lupus erythematosus, Bullouse Bullouse disorders, AD atopic dermatitis, ACD allergic contact dermatitis, AA alopecia areata.