Fig. 6: Identification of three sweep haplotypes at 15 glutathione S-transferase (GST) genes in Ae. aegypti.
From: Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes
a Local detail of latent factor mixed model results around the GST gene region. Data and statistical tests are identical to Fig. 3b,c. Black rectangles indicate the region of 15 GST genes. White-filled circles indicate 32 SNPs beyond the P < 1.956 × 10-5 significance cut-off. b Genotypes at the 32 outlier SNPs identified through latent factor mixed models. Each row represents one individual mosquito, with genotypes shaded by the number of copies of the reference allele. Individuals indicated by the coloured rectangles have two copies of the same 32 SNP haplotype, other plotted individuals had up to one missing or heterozygous site. No other individuals are plotted. SNPs are split into those downstream, upstream, and within the region containing GST genes. The left-hand side y-axis lists the population of origin. The right-hand side y-axis indicates the VSSC genotype (WT = wild-type; V = V1016G background; F-A = F1534C Americas background; F-IP = F1534C Indo-Pacific background). c Locations of Ae. aegypti with two copies of a 32 SNP haplotype (coloured fill) or with one missing or heterozygous site (white fill). Colours indicate the three backgrounds following (b).
