Fig. 1: Epigenetic and transcriptional landscape of CIMP leukemias compared to other leukemias and CD34+ cells. | Nature Communications

Fig. 1: Epigenetic and transcriptional landscape of CIMP leukemias compared to other leukemias and CD34+ cells.

From: Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia

Fig. 1

a Heatmap of the 3000 most variable MCIP-seq regions across all samples (n = 63), displaying their Z-scores and clustered by Euclidean distance. b Diagram depicting different elements of gene regulation and the corresponding data sequenced in this study: MCIP-seq for DNA methylation, H3K27ac ChIP-seq for enhancer activity, ATAC-seq for chromatin accessibility, and RNA-seq for gene expression. c Dimensionality reduction with Uniform Manifold Approximation and Projection (UMAP) of epigenetic and transcriptional data in AML, CIMP, T-ALL and CD34+ HSPCs from healthy donors. From left to right: methylation (MCIP-seq, n = 80), gene expression (RNA-seq, n = 357), histone H3K27 acetylation (H3K27ac, n = 83) measured by ChIP-seq, and open chromatin (ATAC-seq, n = 81). Note that individuals did not completely overlap across all datasets; notably, T-ALL patients in the MCIP-seq cohort were not present in any other experiment (see Supplementary Data 1 for details).

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