Fig. 7: Dysfunctional DCs influenced by CGRP responsible for inducing the suppressive characteristics of CD8+ T cells in MTC. | Nature Communications

Fig. 7: Dysfunctional DCs influenced by CGRP responsible for inducing the suppressive characteristics of CD8+ T cells in MTC.

From: The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

Fig. 7

A Circle plot showing the cell-cell interaction strength of CD86 (left panel) and CD80 (right panel) between T cells and other immune cell types in PTC (green) and MTC (red). B Scatter plot showing the correlation relationship between CGRP expression and the Immune score, the cytotoxic score of CD8+T cell, the dysfunctional score of CD8+T cell and the co-stimulatory score of DCs in tumor bulk-RNA data (n = 14). r indicates the correlation coefficient calculated by Spearman correlation test. C Schematic representation of CGRP-induced immunosuppressive tumor microenvironment in MTC. Source data are provided as a Source Data file. Created with BioRender.com, released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.

Back to article page