Fig. 4: HEARTSVG detects biologically meaningful SVGs in the Slide-seqV2 cerebellum data. | Nature Communications

Fig. 4: HEARTSVG detects biologically meaningful SVGs in the Slide-seqV2 cerebellum data.

From: HEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics

Fig. 4

a Visualization of unsupervised spatial clustering results. b Visualization of cerebellum layer annotations. c Visualizations of spatial expressions and adjusted p-values of representative SVGs of specified cell types detected by HEARTSVG. Car8 (adjusted p-value = 0) in Purkinje cells, Clbn1(adjusted p-value = 1.21e-10) in granule cells and Mbp (adjusted p-value = 0) in oligodendrocytes. P-values were calculated by HEARTSVG and adjusted using Holm’s method. d The tissue-specific enrichment analysis results for each method, where the x-axis represents different tissues, and the y-axis represents the percentage of tissue-specific pathways. Each panel corresponds to each method. e Heatmap of SVGs expressions in Molecular layer, Purkinje layer, and Granule layer. Source data are provided with this paper.

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