Fig. 2: Substrate scope of catalytic cascade difunctionalizations of alkynes. | Nature Communications

Fig. 2: Substrate scope of catalytic cascade difunctionalizations of alkynes.

From: Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions

Fig. 2

Reaction conditions: the reaction was carried out with alkyne 1’ (0.27 mmol), 2 (0.8 mmol), 3 (0.067 mmol), Ni(PCy3)2Cl2 (10 mol%), dtbpy (15 mol%), K2CO3 (0.4 mmol, 2.0 equiv) in the 1 mL of mixed solvent (DMA:DME = 1:1) at 45 oC for 72 h. Unless otherwise stated, all desired polysubstituted 1,3-dienes were obtained with regioselectivity greater than 95:5 and the regioselectivity was detected by 1H NMR analysis of desired products or GC analysis of desired products. DMA = N, N-dimethylacetamide, DME = 1,2-dimethoxyethane.

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