Fig. 4: Molecular modeling of the unique S mutation of SARS-CoV-2 collected from a Virginia opossum.
From: Widespread exposure to SARS-CoV-2 in wildlife communities
a Representation of the structure of the BA.2 S protein (gray, PDB: 7XO8) in its open conformation bound to the human ACE2 (teal). Residues 471 (red) and 798 (orange) are shown as spheres. Glycans are displayed as sticks colored purple. Top inset: Overlay of E471V (red) and BA.2 (gray). Bottom inset: Overlay of G798D (orange) and BA.2 (gray). b Surface map of the BA.2 S protein (left) and the region surrounding E471V and D798G (right) residues. Residue side chain properties are colored: green for hydrophobic, blue for positively charged, red for negatively charged, teal for polar uncharged, and gray for neutral.
