Fig. 6: Predicted products of putative NRP/PKS encoded in bdelloid genomes.
From: Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen
a Secondary metabolite prediction for the full-length annotation AVAG|g48151 (this was preferred over the partially-assembled annotations depicted in Fig. 5b for the A. ricciae ortholog). The PKS-NRPS hybrid cluster corresponding to gene model AVAG|g48151 is predicted by SeMPI 2.0 to synthesise a cyclic heptadepsipeptide. b Maximum common substructures estimated by SeMPI 2.0 are shown (green highlighting) for the two named compounds with the highest similarity to the predicted product: hymenamide J, isolated from extracts of the marine sponge Hymeniacidon sp. and its microbiota, and tyrocidine A, a cyclic decapeptide with potent antifungal activity produced by Bacillus brevis.
