Fig. 7: KDM1A is overexpressed in hepatocellular carcinoma and predicts poor prognosis. | Nature Communications

Fig. 7: KDM1A is overexpressed in hepatocellular carcinoma and predicts poor prognosis.

From: Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma

Fig. 7

a Immunohistochemical staining of KDM1A was performed in 90 pairs of hepatocellular carcinoma tissues and adjacent non-tumoral liver tissues. The representative immunohistochemical staining images of KDM1A were shown (scale bar = 100 μm). b Kaplan–Meier curves showing the relationship between KDM1A expression levels and overall survival (OS)/progression-free survival (PFS). Protein expression high/low groups were determined by the Maxstat R program. The difference between groups was tested by a two-sided Log-rank test. n = 90 samples, High = 18, Low = 72. c Kaplan–Meier curves showing the prognostic (OS) relevance of KDM1A in TCGA (n = 371 samples, High = 76, Low = 295), ICGC (n = 240 samples, High = 116, Low = 124), and GSE14520 (n = 247 samples, High = 129, Low = 118) liver cancer expression profile datasets. d Pearson correlation analysis of KDM1A/ZMYM3 expression levels, liver-TE-related gene expression profiles, and HNF4A downstream gene expression profiles in TCGA, ICGC, and GSE14520 liver cancer datasets. The 3D plot and heatmap display the Pearson correlations of the above values in liver cancer samples. All P-values are significant (P < 0.001). Source data are provided as a Source Data file.

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