Fig. 2: MHC fine-mapping analysis on the association with uRPL.
From: Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss
Regional associations of the imputed HLA variants in the MHC region with uRPL are shown. a Nominal regional associations. b Regional associations conditioned on HLA-C*12:02. c Regional associations conditioned on HLA-B*52:01. d Regional associations conditioned on HLA-DRB1*15:02. e Regional associations conditioned on HLA-C*12:02–HLA-B*52:01–HLA-DRB1*15:02 haplotype. Each diamond represents the −log10(P) of the variants, including the single-nucleotide variants, two-, four-, and six-digit HLA alleles, and amino acid variants of HLA genes. The horizontal dashed line represents the genome-wide significance threshold of P = 5.0 × 10–8. Detailed association results are available in Supplementary Data 1. P-values were computed by logistic regression. All statistical tests are two-sided and unadjusted for multiple comparisons.
