Fig. 3: Associations of HLA-C*12:02–HLA-B*52:01–HLA-DRB1*15:02 haplotype in the stratified analysis.
From: Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss
Odds ratios of HLA-C*12:02–HLA-B*52:01–HLA-DRB1*15:02 haplotype in the stratified analysis are shown. The marker size is proportional to the case sample size. Error bars indicate 95% CI, and the measure of center is the maximum likelihood estimate by logistic regression. case group (A), uRPL cases with confirmed embryonic euploid or undetermined karyotype; case group (B), ANA(+) uRPL cases with confirmed embryonic euploid or undetermined karyotype; case group (C), autoantibody and hypothyroidism(-) uRPL cases with confirmed embryonic euploid or undetermined karyotype; case group (D), uRPL cases with confirmed embryonic euploid; case group (E), uRPL cases with confirmed embryonic aneuploid.
