Table 3 Association summary of the lead HLA alleles and haplotype

From: Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

 

Frequency

  

Allele/Haplotype

Case

Control

OR (95% CI)

P-value

HLA-C*12:02

0.105

0.128

0.67 (0.59–0.76)

1.1 × 10−10

HLA-B*52:01

0.105

0.127

0.67 (0.59–0.76)

1.5 × 10−10

HLA-DRB1*15:02

0.0968

0.118

0.67 (0.59–0.77)

1.2 × 10−9

HLA-C*12:02–HLA-B*52:01–HLA-DRB1*15:02

0.0868

0.108

0.65 (0.57–0.75)

2.8 × 10−10

  1. Two-sided association testing was performed using logistic regression. P-values are unadjusted for multiple comparisons.
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