Fig. 2: Genome-wide novel and refined SNP associations with baseline obesity estimated over the measurement window for each individual. | Nature Communications

Fig. 2: Genome-wide novel and refined SNP associations with baseline obesity estimated over the measurement window for each individual.

From: Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

Fig. 2

A Combined Manhattan plot displaying genome-wide SNP associations estimated using linear mixed-model tests in BOLT-LMM84 with obesity trait (BMI or weight) across female, male, and sex-combined analysis strata. Each point represents an SNP, with genome-wide significant (GWS) SNPs (P < 5 × 10−8) coloured in green for previously published obesity associations, blue for SNPs in LD (r2 > 0.1) with published associations, yellow for refined SNPs that represent conditionally independent (Pconditional < 0.05) and stronger associations with baseline obesity than published SNPs in the region, and pink for novel associations (see Methods47). Novel SNPs are annotated to their nearest gene. B Proportion of variance in baseline BMI and weight that can be explained by the fine-mapped independent lead SNPs in each strata. In green is the proportion of variance explained by previously published obesity-associated variants (and those in LD with these variants), while that explained by novel and refined variants is in pink. The numbers represent the number of lead SNPs in each of these categories (published/refined and novel).

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