Fig. 3: rs781745126-T carriers have reduced LAG-3 expression on surface of activated CD4+ and CD8+ T-cells. | Nature Communications

Fig. 3: rs781745126-T carriers have reduced LAG-3 expression on surface of activated CD4+ and CD8+ T-cells.

From: Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease

Fig. 3

Peripheral blood mononuclear cells (PBMCs) from 25 heterozygous rs781745126-T carriers (CT, blue) and 25 non-carrier controls (CC, red) matched for age and sex were stimulated with anti-CD3/anti-CD28 beads for 6 days to induce LAG-3 expression and proliferation. a LAG-3 surface expression on CD4+ and CD8+ T-cells (geometric mean fluorescense intensity, gMFI) and (b) frequency of proliferating cells analyzed on day 6, using cell trace violet (CTV) stain. Paired t-test with two-sided P-values was used to compare carriers (blue) and non-carriers (red).

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